First-ever heart transplant from gene-edited pig offers hope for thousands in need of organs

The pig was genegineered to have a heart that would not be rejected by a human immune system, so that human blood would not coagulate within it, and so that the pig would not grow too big (at one year old it was 240 pounds, when otherwise it would have been about 450 pounds).

That’s cool and all, but I imagine that the technique that will eventually win in the future will be hearts (and other organs) cloned from the patient themselves, with whatever genetic modifications to prevent whatever the problem was in the first place. At first that will probably mean organs grown in machines (perhaps even 3D printed), but someday I suspect that your new heart might well be grown in place. Exactly *how* that will happen, I don’t know: maybe the new heart grows next to the old one, starting small and gradually taking it’s place, so for a while you have two beating hearts. Or maybe the new cloned heart will grow *in* the old one… a few scattered new, modified cells seeded throughout the old damaged heart, consuming and replacing the old heart like The Thing, so that it looks like the heart is rapidly repairing itself when in fact it’s being repalced. In the end such a therapy will be of no greater drama than getting a shot of antibiotics today, but the years, perhaps decades, spent perfecting it will doubtless have some exciting failures and screwups.